PittsburghV1, Canada, Analysis, bibRecord, 000572

Phase II Study of Weekly Vinblastine in Recurrent or Refractory Pediatric Low-Grade Glioma

Identifieur interne : 000572 ( Canada/Analysis ); précédent : 000571; suivant : 000573

Phase II Study of Weekly Vinblastine in Recurrent or Refractory Pediatric Low-Grade Glioma

Auteurs : Eric Bouffet [Canada] ; Regina Jakacki [États-Unis] ; Stewart Goldman [États-Unis] ; Darren Hargrave [Royaume-Uni] ; Cynthia Hawkins [Canada] ; Manohar Shroff [Canada] ; Juliette Hukin [Canada, États-Unis] ; Ute Bartels [Canada] ; Nicholas Foreman [États-Unis] ; Stewart Kellie [Australie] ; Joanne Hilden [États-Unis] ; Michael Etzl [États-Unis] ; Beverly Wilson [Canada] ; Derek Stephens [Canada] ; Uri Tabori [Canada] ; Sylvain Baruchel [Canada]

Source :

Journal of clinical oncology [ 0732-183X ] ; 2012.

RBID : Pascal:12-0196668

Descripteurs français

Pascal (Inist)
- Essai clinique phase II, Traitement, Rythme administration, Vinblastine, Récidive, Résistance traitement, Bas grade, Enfant, Pédiatrie, Gliome, Cancérologie, Anticancéreux.
Wicri :
- topic : Enfant, Pédiatrie.

English descriptors

KwdEn :
- Administration schedule, Antineoplastic agent, Cancerology, Child, Glioma, Low grade, Pediatrics, Phase II trial, Relapse, Treatment, Treatment resistance, Vinblastine.

Abstract

Purpose To evaluate the efficacy of single-agent vinblastine in pediatric patients with recurrent or refractory low-grade glioma. Patients and Methods Patients were eligible if they had experienced previous treatment failure (chemotherapy and/or radiation) for incompletely resected or unresectable low-grade glioma (LGG). Vinblastine (6 mg/m²) was administered weekly for 1 year unless unacceptable toxicity or progression (confirmed on two consecutive imaging studies) occurred. Results Fifty-one patients (age range, 1.4 to 18.2 years; median age, 7.2 years) were prospectively enrolled onto this phase II study. Fifty patients had previously received at least one prior regimen of chemotherapy, and 10 patients had previously received radiation treatment. Fifty patients were evaluable for response; 18 patients (36%) had a complete, partial, or minor response, and 31 patients completed 1 year of treatment. At a median follow-up of 67 months, 23 patients had not experienced progression; three patients have died. Five-year overall survival was 93.2% ± 3.8%, and 5-year progression-free survival was 42.3% ± 7.2%. Toxicity was manageable and mostly hematologic, although a few patients needed transfusions. Conclusion Weekly vinblastine seems to be a reasonable alternative to radiation for pediatric patients with LGG who have experienced treatment failure with first-line chemotherapy. The 5-year progression-free survival observed in this phase II trial is comparable to results observed with first-line chemotherapy in chemotherapy-naive patients. The role of single-agent vinblastine and other vinca alkaloid in the management of pediatric LGGs deserves further investigation.

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream PascalFrancis, to step Curation: 000B59
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Pascal:12-0196668

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Phase II Study of Weekly Vinblastine in Recurrent or Refractory Pediatric Low-Grade Glioma</title>
<author><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name>
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<author><name sortKey="Jakacki, Regina" sort="Jakacki, Regina" uniqKey="Jakacki R" first="Regina" last="Jakacki">Regina Jakacki</name>
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<author><name sortKey="Goldman, Stewart" sort="Goldman, Stewart" uniqKey="Goldman S" first="Stewart" last="Goldman">Stewart Goldman</name>
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<country>Australie</country>
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<author><name sortKey="Hilden, Joanne" sort="Hilden, Joanne" uniqKey="Hilden J" first="Joanne" last="Hilden">Joanne Hilden</name>
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<author><name sortKey="Etzl, Michael" sort="Etzl, Michael" uniqKey="Etzl M" first="Michael" last="Etzl">Michael Etzl</name>
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<country>États-Unis</country>
<wicri:noRegion>Phoenix Children's Hospital</wicri:noRegion>
</affiliation>
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<author><name sortKey="Wilson, Beverly" sort="Wilson, Beverly" uniqKey="Wilson B" first="Beverly" last="Wilson">Beverly Wilson</name>
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<s2>Edmonton, Alberta</s2>
<s3>CAN</s3>
<sZ>13 aut.</sZ>
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</affiliation>
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<author><name sortKey="Stephens, Derek" sort="Stephens, Derek" uniqKey="Stephens D" first="Derek" last="Stephens">Derek Stephens</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Hospital for Sick Children, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Tabori, Uri" sort="Tabori, Uri" uniqKey="Tabori U" first="Uri" last="Tabori">Uri Tabori</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Hospital for Sick Children, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Baruchel, Sylvain" sort="Baruchel, Sylvain" uniqKey="Baruchel S" first="Sylvain" last="Baruchel">Sylvain Baruchel</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Hospital for Sick Children, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of clinical oncology</title>
<title level="j" type="abbreviated">J. clin. oncol.</title>
<idno type="ISSN">0732-183X</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of clinical oncology</title>
<title level="j" type="abbreviated">J. clin. oncol.</title>
<idno type="ISSN">0732-183X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration schedule</term>
<term>Antineoplastic agent</term>
<term>Cancerology</term>
<term>Child</term>
<term>Glioma</term>
<term>Low grade</term>
<term>Pediatrics</term>
<term>Phase II trial</term>
<term>Relapse</term>
<term>Treatment</term>
<term>Treatment resistance</term>
<term>Vinblastine</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Essai clinique phase II</term>
<term>Traitement</term>
<term>Rythme administration</term>
<term>Vinblastine</term>
<term>Récidive</term>
<term>Résistance traitement</term>
<term>Bas grade</term>
<term>Enfant</term>
<term>Pédiatrie</term>
<term>Gliome</term>
<term>Cancérologie</term>
<term>Anticancéreux</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term>
<term>Pédiatrie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose To evaluate the efficacy of single-agent vinblastine in pediatric patients with recurrent or refractory low-grade glioma. Patients and Methods Patients were eligible if they had experienced previous treatment failure (chemotherapy and/or radiation) for incompletely resected or unresectable low-grade glioma (LGG). Vinblastine (6 mg/m<sup>2</sup>
) was administered weekly for 1 year unless unacceptable toxicity or progression (confirmed on two consecutive imaging studies) occurred. Results Fifty-one patients (age range, 1.4 to 18.2 years; median age, 7.2 years) were prospectively enrolled onto this phase II study. Fifty patients had previously received at least one prior regimen of chemotherapy, and 10 patients had previously received radiation treatment. Fifty patients were evaluable for response; 18 patients (36%) had a complete, partial, or minor response, and 31 patients completed 1 year of treatment. At a median follow-up of 67 months, 23 patients had not experienced progression; three patients have died. Five-year overall survival was 93.2% ± 3.8%, and 5-year progression-free survival was 42.3% ± 7.2%. Toxicity was manageable and mostly hematologic, although a few patients needed transfusions. Conclusion Weekly vinblastine seems to be a reasonable alternative to radiation for pediatric patients with LGG who have experienced treatment failure with first-line chemotherapy. The 5-year progression-free survival observed in this phase II trial is comparable to results observed with first-line chemotherapy in chemotherapy-naive patients. The role of single-agent vinblastine and other vinca alkaloid in the management of pediatric LGGs deserves further investigation.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Ontario"><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name>
</region>
<name sortKey="Bartels, Ute" sort="Bartels, Ute" uniqKey="Bartels U" first="Ute" last="Bartels">Ute Bartels</name>
<name sortKey="Baruchel, Sylvain" sort="Baruchel, Sylvain" uniqKey="Baruchel S" first="Sylvain" last="Baruchel">Sylvain Baruchel</name>
<name sortKey="Hawkins, Cynthia" sort="Hawkins, Cynthia" uniqKey="Hawkins C" first="Cynthia" last="Hawkins">Cynthia Hawkins</name>
<name sortKey="Hukin, Juliette" sort="Hukin, Juliette" uniqKey="Hukin J" first="Juliette" last="Hukin">Juliette Hukin</name>
<name sortKey="Shroff, Manohar" sort="Shroff, Manohar" uniqKey="Shroff M" first="Manohar" last="Shroff">Manohar Shroff</name>
<name sortKey="Stephens, Derek" sort="Stephens, Derek" uniqKey="Stephens D" first="Derek" last="Stephens">Derek Stephens</name>
<name sortKey="Tabori, Uri" sort="Tabori, Uri" uniqKey="Tabori U" first="Uri" last="Tabori">Uri Tabori</name>
<name sortKey="Wilson, Beverly" sort="Wilson, Beverly" uniqKey="Wilson B" first="Beverly" last="Wilson">Beverly Wilson</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Jakacki, Regina" sort="Jakacki, Regina" uniqKey="Jakacki R" first="Regina" last="Jakacki">Regina Jakacki</name>
</noRegion>
<name sortKey="Etzl, Michael" sort="Etzl, Michael" uniqKey="Etzl M" first="Michael" last="Etzl">Michael Etzl</name>
<name sortKey="Foreman, Nicholas" sort="Foreman, Nicholas" uniqKey="Foreman N" first="Nicholas" last="Foreman">Nicholas Foreman</name>
<name sortKey="Goldman, Stewart" sort="Goldman, Stewart" uniqKey="Goldman S" first="Stewart" last="Goldman">Stewart Goldman</name>
<name sortKey="Hilden, Joanne" sort="Hilden, Joanne" uniqKey="Hilden J" first="Joanne" last="Hilden">Joanne Hilden</name>
<name sortKey="Hukin, Juliette" sort="Hukin, Juliette" uniqKey="Hukin J" first="Juliette" last="Hukin">Juliette Hukin</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Hargrave, Darren" sort="Hargrave, Darren" uniqKey="Hargrave D" first="Darren" last="Hargrave">Darren Hargrave</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Kellie, Stewart" sort="Kellie, Stewart" uniqKey="Kellie S" first="Stewart" last="Kellie">Stewart Kellie</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Phase II Study of Weekly Vinblastine in Recurrent or Refractory Pediatric Low-Grade Glioma

Phase II Study of Weekly Vinblastine in Recurrent or Refractory Pediatric Low-Grade Glioma

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